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Provigil vs Nuvigil - Modafinil Generic vs Brand

In case you were wondering which one is better – Provigil vs Nuvigil, we have to say the answer won’t be as simple as you were hoping for. 

We are talking about two prescription drugs that have the ability to remove or prevent symptoms of several sleep disorders but also to provide you with great cognitive enhancement. 

What you should know right on is that they are very similar, with very few differences we are going to explain in the lines that follow, and that it probably won’t make a massive difference if you choose to go with either one of them.

This article and all other content created by Moda Wiki is for informational purposes only. It is created for your entertainment. This is not legal or medical advice. Always make sure to seek the advice of your primary physician or medical professional before consuming nootropics, like Modafinil, or other pharmaceutical drugs. Please read our disclaimer.

Nuvigil is a brand name Armodafinil that’s defined as a wakefulness-promoting agent. It is a pharmaceutical that has an ability to treat extensive sleepiness caused by narcolepsy, shift work sleep disorder, obstructive sleep apnea, and some other sleep disorders. 

Even though it is a Schedule IV, prescription-only medication in most western countries, and that it should be used under a doctor’s supervision, many people often consume it as a stimulant that can affect our cognitive skills, our memory, focus, motivation, and alertness. Nuvigil is a newer drug compared to Provigil, and it comes in 50, 150, 200 and 250mg pills.

What is Provigil?

Nuvigil and Provigil have the same active ingredients, and just a slightly different structure. They are both nootropics that promote wakefulness, and they both treat symptoms of the same medical conditions – OSA, narcolepsy, and SWD. It’s important to underline that these smart drugs cannot treat these conditions per se, but only the fatigue and daytime sleepiness that comes as a result of them. Also, they can be used for some other treatments, like for dealing with symptoms of ADHD.

Besides that, both Nuvigil and Provigil are proved to be great cognitive enhancers and stimulants that will improve people’s focus, alertness, motivation, concentration and memory retention. They will bring up the level of overall performance. It is unknown how exactly these drugs work, their precise mechanism of action is still being researched, but it is confirmed that they affect the level of dopamine and histamine in our brain. That’s why they both affect people’s mood and make them more motivated. So when it comes to Nuvigil vs Provigil reviews, the results are pretty much tied.

They both come in the shape of round pills and should be consumed in the early morning hours, with or without food. That’s important for two reasons – first, users of these nootropics will that way be in a situation to enjoy all their benefits of drugs during working hours when they usually need stimulation, and second, they won’t be in a position to deal with insomnia, which can get in a way if a drug of this kind is taken later during the day.

Their half-life is also the same – Nuvigil and Provigil will stay in our system for around 12 to 15 hours, and they both have generic versions available in the market. They are both categorized as Schedule IV substances, which means they have the status of prescription-only pharmaceuticals in most western countries, and they are FDA-approved.

Differences between Nuvigil and Provigil

After we have established there are a lot of similarities regarding these two nootropics, it is time to move on Nuvigil vs Provigil differences. But the fact is, there aren’t many of them. We can say that Nuvigil is a bit stronger drug than Provigil and that it can provide a more powerful energy boost after you take the pill. They will both need around an hour and a half to fully kick in after you take a pill, but during the next several hours one may notice that Nuvigil has a slightly stronger effect.

When it comes to Nuvigil vs Provigil dose, the difference speaks in favour of this previous claim. Provigil users are advised to take 200mg a day, while those who use Nuvigil should take 150mg a day. These doses of drugs will provide you with pretty much the same benefits and same half-life, but the fact is 150mg of Nuvigil will do the same as 200mg of Provigil.

Their prices are something that varies and can be affected by several things, but in general, Provigil is more expensive than Nuvigil. You can purchase 30 Provigil tablets of 200mg for around $1900, while 30 pills of 150mg Nuvigil will be little less than $900. Bear in mind that you can get these drugs way cheaper if you are covered with medical insurance. Also, generic versions of Nuvigil and Provigil are much more affordable and can be found in most online stores. But let’s be honest, in the matter of Provigil vs Nuvigil cost, Nuvigil is definitely a winner.

Side effects

Intake of every drug brings the possibility of side effects showing after some time. It’s the same with Provigil and Nuvigil. Given that we are talking about pretty similar pharmaceuticals, their side effects are pretty much the same. The most common ones are headache, dizziness, nausea, anxiety, insomnia, dry mouth, diarrhea, dehydration, and stomach pain, while Provigil may cause additional back pain and stuffy nose. Now, they are all easy to handle and won’t endanger your health.

But there are ways to prevent some of them from happening. For example, if you don’t mix Nuvigil or Provigil with alcohol, you will probably avoid having a severe headache. Besides that, the intake of alcohol is not recommended when using these nootropics. Also, if you drink enough water during the day, around three litres, you won’t experience dry mouth or dehydration. And in order not to face insomnia, you just have to take the pill of Provigil or Nuvigil in the early morning hours so that drug effects pass by the time you go to bed.

When it comes to more serious side effects, you should know that they are rarely happening, but if they do, you should seek medical help and stop with smart drug intake. There are reports of people having problems with chest pain, increased blood pressure, hallucinations, increased heartbeat, severe skin rash, allergic reactions, mania, and trouble breathing, but as we already said, those situations are extremely rare.

Drug interactions

If you wonder what’s the deal with Nuvigil vs Provigil drug interactions, we can say that they both can interact with other medications and that it can lead to more serious side effects, or to a situation where the drugs will be less effective. If you are currently taking some pharmaceuticals, you should consult with your doctor and inform him of that. He can avoid this from happening by simply adjusting the dosage of Nuvigil or Provigil you are prescribed to use. 

These nootropics can interact with birth control pills, Cyclosporine, Triazolam, Midazolam, Phenytoin, Propranolol, Diazepam, Omeprazole, Clomipramine, etc. It is crucial that you don’t use these nootropics on your own in case you are having some sort of liver problems, heart issues, kidney disease, high blood pressure, or some mental conditions or diagnosis.

Which one is more effective?

It is hard to say which one of these smart drugs is more effective given they are so alike in many aspects. They will provide you with the same benefits, and they can be used for treating symptoms of the same conditions. In the case of their off-label usage, both Nuvigil and Provigil will enhance your cognitive functions, they will make sure you have better memory retention, better focus, increased motivation and concentration. 

Also, they will make sure the fatigue and daytime drowsiness are out of the picture. But it is concluded that Nuvigil is a bit more powerful than Provigil, even though that’s mostly the subjective feeling people may or may not have. Some claim Nuvigil is the winner while others are praising Provigil as the best possible smart drug you can find in the market. And most of them tried both of these nootropics.


Can Nuvigil or Provigil lead to weight loss?

According to several studies and clinical trials, there is a low rate of serum aminotransferase and alkaline phosphatase elevations associated with Modafinil (Provigil) and Armodafinil (Nuvigil). Up until now, there are no reports of either of these drugs causing liver damage or any sort of injury of that kind.

Can I use Nuvigil or Provigil every day?

You can, but that’s not recommended. Most experts claim that it would be best to use these nootropics only when prescribed, or, in case of their off-label usage, only when needed. If you plan on using them more often, make sure not to take a daily dosage of Nuvigil or Provigil more often than once to three times a week. 

Continuous intake of these nootropics can cause their effectiveness to lose its continuity and their intensity. That’s why people sometimes feel like the same dosage of these smart drugs after some time isn’t doing the work like before, which leads to increasing their dosage.


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