modafinil interactions featured image

Modafinil Interactions

The age of burnout, anxiety, excessive and constant tiredness and not-so-occasional depressive feelings has got us all into a state of overwhelming unease that, often, requires more powerful (and quicker) remedies than meditation or any other form of holistic release.

In need of improved focus, improved brain function and cognitive performance, as well as increased energy levels, most people of the 21st century have turned to nootropics – a class of substances regulated and approved by the FDA – known to boost brain performance. Frequently, they are referred to as cognition enhancers or memory-enhancing substances.

Nootropics can be prescribed and over-the-counter (nonprescription substances), each used for a specific set of conditions.

Prescribed nootropics are mostly used to counteract the symptoms of medical conditions such as narcolepsy, attention deficit hyperactivity disorder (ADHD), SWSD, Sleep Apnea, or Alzheimer’s disease. The over-the-counter nootropic options are usually used as everyday wellness boosters, i.e. for studying concentration, improved sex drive, weight loss, and similar. Although Modafinil and bodybuilding are commonly linked, there is no scientific proof of Modafinil positively affecting bodybuilders’ routines.

This article and all other content created by Moda Wiki is for informational purposes only. It is created for your entertainment. This is not legal or medical advice. Always make sure to seek the advice of your primary physician or medical professional before consuming nootropics, like Modafinil, or other pharmaceutical drugs. Please read our disclaimer.

These nootropics include:

  • Modafinil (Provigil), most prominently used to address the sudden drowsiness of narcolepsy
  • Adderall, commonly used to treat ADHD
  • Memantine (Axura), known to treat symptoms of Alzheimer’s disease
  • Methylphenidate (Ritalin), often used to manage symptoms of ADHD and narcolepsy

Although being very effective in treating specific conditions/diseases, these nootropics should not be used without a prescription. If a person is taking Modafinil, Adderall, Memantine, or Methylphenidate, they should be aware of the fact that every nootropic, just like any prescription medication, carries the risk of side effects, in particular during interactions.

Common side effects of prescription nootropics include but are not limited to:

  • Addiction
  • High blood pressure
  • A fast heart rate
  • Trouble with vision
  • A higher risk of impulsive behaviors (e.g. risky sexual practices)
  • Insomnia and other sleep disturbances

Supervised and responsible nootropic consumption should manage any potential side effects.

Over-the-Counter Nootropics

While some of the most popular nootropics on the market such as Modafinil are often successfully used without a prescription but do recommend one, some nootropics do not require a prescription and are available on the free market.

These nootropics are:

  • Caffeine (beverages containing Caffeine)
  • L-theanine
  • Omega-3 fatty acids
  • Racetams (e.g. piracetam, pramiracetam, phenylpiracetam, aniracetam)
  • Ginkgo biloba
  • Panax ginseng
  • Rhodiola
  • Creatine

What Happens When Different Nootropics Are Mixed in an Uncontrolled Environment?

With the nootropic market actively expanding, it is easy to get unreliable information that may potentially harm one’s health. When choosing a nootropic, a person should not only do research by themselves but also consult a professional. Every nootropics consumption can result in both benefits and harmful side effects if not taken responsibly. However, mixing the right nootropics will potentiate their benefits, while combining the wrong ones may potentiate their side effects.

Being the safest and most commonly prescribed among all nootropics, Modafinil has gained a reputation for being not only effective for everything that it is sold for but also the most reliable to combine with other nootropics. However, Modafinil combinations are a high-risk and high-reward type of nootropic cocktails. 

For example, Modafinil and alcohol do not mix well (i.e. Modafinil alcohol interaction has proven to result in serious side effects). At the same time, Modafinil and Caffeine can be an excellent pairing under the right circumstances. But what about mixing it with other, prescription nootropics like Phenibut, Ritalin, Adderall, and Adrafinil?

Modafinil and Phenibut

Is Modafinil and Phenibut a safe combination? Both Modafinil and Phenibut have their good and not-so-good properties, but the combination of the two seems to result in an almost normally-impossible-to-achieve-result.

The interaction of these two grants the consumer incredibly strong brain power without jeopardizing their composure. Modafinil pills increase motivation and focus, while Phenibut keeps that pesky anxiety at bay. Mostly, one gets their performance at work, school or other kinds of social environments boosted all while keeping their calm manner. 

However, as is the case with most of the nootropic combinations, possible Phenibut and Modafinil side effects can be a real hassle. Those include but are not limited to:

  • Tummy issues: nausea, diarrhea, vomiting, indigestion
  • Various psychological problems: anxiety, anorexia, emotional lability, agitation, headaches, dizziness, insomnia, excessive sweating, drowsiness, back pain, and chills

When used in an uncontrolled environment and irresponsibly, a person may experience Phenibut-Modafinil withdrawal which could result in shortness of breath, brain fog, heart palpitations, problems with appetite, concentration, muscle tension, to name a few.

The nootropic battle between Modafinil and Phenibut in terms of which one is better to use may vary greatly on your preferences, desired goals, and physical predispositions.

Unlike Modafinil that is a stimulant predominantly used to treat narcolepsy, ADHD, and SWSD, and is commonly referred to as a “smart drug”, Phenibut was developed to treat post-traumatic stress disorder, and it’s a byproduct of gamma-aminobutyric acid (GABA). GABA works by attaching itself to GABAA and GABAB receptors, resulting in reduced anxiety, stress, improved sleep quality, and memory. Phenibut is sometimes even prescribed to treat alcohol withdrawal.

Moreover, Phenibut helps with depression, stuttering, anxiety, and plenty of other conditions and/or disorders. Its recommended dosage can vary significantly on a person’s health, stamina, and additional circumstances.

Modafinil and Ritalin

Modafinil and Ritalin may be one of the most commonly mentioned nootropic combinations out there and for a reason. While individually both nootropics help with a person’s mental performance, Modafinil and Ritalin combined do have a particular side-effect.

Users of this nootropic cocktail have reported memory loss after the effect of two had worn off. In fact, the combination of the two nootropics seems to help individuals stay extraordinarily productive while “under the influence”. However, once the effect wears off, those same individuals report memory loss and/or difficulty to recall what they had done in the previous hours. 

This has mostly been reported by students who used the combination to study, but then forgot all the information they acquired once the effect of Modafinil and Ritalin wore off. So, should you take them together? Consult with your doctor before making that decision.

Modafinil and Adderall

Modafinil safety has often been researched through its interaction with other similar nootropics. Modafinil and Adderall are a common nootropic combination, especially in e-sports and gaming industries consumers which prompted the Electronic Sports League (ESL) to introduce a drug screening in the days to come. But, does Modafinil show on drug tests, at all? That depends.

While Modafinil tends to be highly unlikely to read on a regular drug test, the athletic commissions often use expensive and elaborate tests that can identify all kinds of chemicals in a person’s system. Even though Modafinil is not on the National Collegiate Athletic Association (NCAA) ‘s list of banned substances, they do state that stimulants are generally not allowed. So, how should one test for Modafinil properly?

The research conducted did not only lead the experts to establish Modafinil (in)visibility on drug tests, but it has also given everyone an insight into ways drug tests actually work. From Reagent Testing and Immuno-Assay to Gas Chromatography, Mass Spectronomy, and Panels – there are plenty of ways that determine the presence of drugs/substances in one’s blood.

New studies and user-experience on Modafinil and Adderall joint consumption suggests Modafinil, which is not a stimulant but acts similar to one in many ways, can be risky when taken with Adderall. Unlike Modafinil, Adderall induces euphoria and is considered addictive. On the other hand, Modafinil is not addictive; it is a nootropic that is regarded as safer and gentler in its effect, together with being a more effective cognitive enhancer.

If two stimulant-like substances are consumed at once, they may cause over-stimulation, which then can increase the risk of the side effects of one or either of these drugs. Nausea, anxiety, or headache are common side effects if Modafinil and Adderall taken together.

Modafinil and Adrafinil

Similarly to Modafinil and Adderall cross tolerance, Modafinil and Adrafinil seem to be a combination that is not typically recommended for regular use. Both of these nootropics increase Dopamine, Norepinephrine, Orexin, and Histamine in one’s system, helping students and business people alike stay on top of their demanding schedules. However, while Modafinil is proven harmless (aside from its commonly known side-effects), Adrafinil is a prodrug that can have a negative impact on a consumer’s liver, i.e. damage it. This is why you should avoid Adrafinil altogether. If you do decide to combine Modafinil and Adderall, make sure you consult your doctor first.

Modafinil and Neurochemistry

Modafinil is a controlled drug prescribed for ADHD and narcolepsy, but its off label uses are far more colorful. Predominantly, Modafinil is used for concentration, motivation, weight loss, wakefulness and others. But how does Modafinil change one’s brain chemistry?

The reason why Modafinil is as effective is owing to the four neurotransmitters in our brains: Orexin, Dopamine, Norepinephrine, Histamine. In unison with Modafinil, each of the neurotransmitters reacts differently; getting all the information on Modafinil and neurotransmitters’ interaction can increase the nootropics’ perks and potentially decrease Modafinil risks and side-effects.

Modafinil and Orexin

Modafinil is usually mentioned as a wakefulness-promoting drug, fighting narcolepsy, and helping people go on with their day undisrupted. Interestingly, the market has recently seen a rise of Orexin, a drug opposite to Modafinil in its effect. Unlike Modafinil that is promoting wakefulness, Orexin is promoting sleep.

Orexins, also called hypocretins, are hypothalamus-produced chemicals involved in wakefulness and arousal. People with narcolepsy suffer a loss of orexin-producing neurons in that area of the brain. Typically, in people suffering narcolepsy, Modafinil is the nootropic that gets prescribed. When Modafinil activates all neurons vital for wakefulness, alertness, and motivation – a person becomes much more ready to go on about their day. Furthermore, their functionality improves significantly, along with their productivity.

Recently, a new nootropic Orexin has been in development, announced to block the signaling of the chemical orexin in the brain and therefore promote sleep. At this point, Modafinil and Orexin interaction is unknown.

Modafinil and Dopamine

Is there a correlation between Modafinil and Dopamine? There is. Besides being involved in regulating hormone balance in men and women, Dopamine also plays a significant role when it comes to sleep regulation.

Modafinil blocks Dopamine transporters, and consequently, it stops Dopamine re-absorption into synapses, making Dopamine free to circulate extracellular areas without disappearing. Lack of Dopamine in one’s brain leads to poor concentration, ADHD and various other cognitive dysfunctions which is why Modafinil is usually prescribed to help regulate these levels. Essentially, Modafinil and Dopamine interaction results in Dopamine levels rising, and a person’s reward centre waking up.

Modafinil and Norepinephrine

Modafinil as a nootropic is often responsible for sleep-wake cycle regulation, and it is usually mentioned through its interaction with Norepinephrine/Noradrenaline. Norepinephrine (in unison with Dopamine, Histamine, Orexin, and a lot of other chemicals) is heavily involved in the sleep-wake cycle through its activity in locus coeruleus, an important part of the hypothalamus.

The way Modafinil acts in the case of Noradrenaline is very similar to its treatment of Dopamine – it inhibits its reuptake, establishing an effect on a person’s wakefulness, focus, and motivation. It is important to note that many Modafinil side effects come from too much of norepinephrine in our bloodstream.

Modafinil and Histamine

Another brain chemical, Histamine, in interaction with Modafinil, releases up to 150% of the chemical, based on specific research. Histamine is found all over the body, influencing the contractions of the smooth muscle of the stomach, lungs, uterus, blood vessels, and, consequently – blood pressure. Moreover, Histamine keeps itself busy with its “protector” duties, protecting us from physical damage, infection, or allergic reactions. Essentially, when consumers are in need of enhanced Histamine release, Modafinil may help.

Modafinil Interactions: Where do Caffeine and Alcohol Fit In?

Additionally promoted as a “smart drug”, Modafinil is often the first choice of students who need a cognitive boost, or business people with demanding schedules. Progressive fatigue, paired with plunging concentration tend to lead to uncontrolled substance consumption or even substance abuse. Modafinil and alcohol seem to be one of the most commonly mixed substances, be that the result of purposeful or unintentional action. It is safe to say that mixing Modafinil and alcohol is, in no way, helpful and can be harmful to the liver.

Modafinil and Alcohol

Modafinil and alcohol blackout will not be likely to happen, but the combination of the two may result in poor judgment and an increased feeling of drowsiness. While alcohol decreases one’s intellectual capacities and focus, Modafinil does the opposite and is intended to boost a fresh, unintoxicated brain for maximum result. Joint Modafinil and alcohol consumption are not recommended; but, if it happens that the two get consumed at the same time, drinking plenty of water will help clean the combination out of your system.

Modafinil and Caffeine

Caffeine is one of the most commonly consumed over-the-counter nootropics, available without a prescription and often consumed as a regular, everyday drink. However, is Modafinil and Caffeine mix a combination to be entertained often?

Being in the same class of drugs, these two substances may lead to a person getting overstimulated. Still, when consumed reasonably, Modafinil and Caffeine together can lead to fantastic productivity and wakefulness. However, it is essential to note that one should not consume more than 200 mg of Caffeine every six hours. On average, a coffee cup contains around 100 mg of Caffeine, while black tea can have anywhere up to 70 mg. Green tea contains up to 45 mg per cup. So, if you are taking a regular dosage of Modafinil, make sure you do not go over the recommended Caffeine dosage per day.

Most people take their Modafinil with the first cup of morning coffee or their Caffeine pill, but this type of consumption depends solely on the individual. Side effects like insomnia, jitteriness, palpitations, and muscle tremors are all possible, but not very likely. So, downsize the dosage of either if you feel overstimulated and want to avoid Modafinil and Caffeine anxiety.

Modafinil Interactions with LSD, Weed and Valium

Modafinil and Valium make an interesting combination, as Modafinil tends to increase the blood levels and effects of Valium. In case you are prescribed both medications, trust in your doctor to recommend the right dosage. If, however, you are taking one or both medications without a prescription, be prepared to experience side-effects and discomfort, as neither of the two should be taken carelessly. 

Don’t ever drink alcohol with Valium as it can increase the effects of the drug, leading to impaired judgment, drowsiness, tiredness, tiredness, and distress.

Presently, there are no credible resources studying the interaction between Modafinil and LSD nor Modafinil and weed which is why the combinations are not recommended for use. If, for any reason, you find yourself combining the two substances or you desire to combine them in the future for recreational or some other purposes, consult with your doctor prior.

Final Thoughts

Branded as one of the safest and most productivity-beneficial nootropics on the market, Modafinil has, for a reason, gained incredible popularity among its regular and potential users. As Modafinil is an artificially created substance, it is essential to master its interactions with brain chemicals and other nootropics to make use of its primary and secondary functions with no harm whatsoever.

Whoever is taking Modafinil should not only get educated on the substance but also buy the product from trusted vendors to avoid suffering any health difficulties or Modafinil not working.

Similar Posts